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Advantages
TR Caps™ markets time release nutritional supplements in pellets. The pellets are made in pharmaceutical approved facilities and utilize advanced Swiss technology.
TATA Advantages of time release pellets:
TIME: Longer benefits
The TR Caps™ product disintegrates slowly as it passes through the gastro intestinal tract. Apart from formulations that are immediately absorbed or are absorbed at specific sites, the time release mechanism slows the rate of release of the ingredient providing for better absorption. In order to obtain a time release product, the active ingredients need to be surrounded by a membrane. This action is depicted in the diagram below, as the membrane protects the active ingredient throughout the disintegration period, which for most time release formulations is between 4 and 24 hours.
Diagram of a Pellet
ACTIVITY: Pop less pills
Conventional dosage forms are not able to control the target area of administration and are released immediately. This necessitates frequent administration in order to maintain an effective level. As a result, the ingredient’s concentration widely fluctuates as it can be initially high and then quickly fall (refer to immediate release diagram below). In contrast, time release dosage forms are not only able to maintain effective levels with smooth release rates, but also require less dosing (refer to time release diagram below).










TYPE: Better product
Multiple-unit dosage forms disintegrate into several sub-units after ingestion. Single-unit dosage forms primarily tablets can generate adverse effects such as a sour stomach or gastric irritation due to their inability to disintegrate into small particles after ingestion. When a product is transported as a single unit, instead of many sub-units, the lack of distribution within the GI tract can yield adverse effects as the ingredients are released in one specific area.
Tablet Tract
AREA: Homogeneous effects
The TR Caps™ dose consists of over 300 homogeneous pellets or sub-units with various ingredients and different release characteristics. Since gastrointestinal (GI) transit time is of major importance to a time release product’s effectiveness, if an ingredient’s time release profile is not specific, an ingredient that is unstable in the acidic conditions of the stomach or that is only absorbed within a defined part of the intestinal tract will prove ineffective. Therefore, the flexibility and properties of multiple-units show clear advantages over single-unit formulations.
Maintaining the products' effects
Ingredients that the body eliminates very quickly need to be sustained within a precise therapeutic range. This can be challenging to achieve with immediate release formulations (i.e. tablets or powder). If an ingredient has a short life and is eliminated from the body too quickly to provide a therapeutic benefit, frequent dosing may be required creating safety and compliance issues. The time release technology improves performance and reduces side effects due to its slow release within a precise therapeutic range.
The topics discussed above illustrate and detail the creation of an entirely new generation of dietary supplements.
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